艾滋病毒/Talaromyces marneffei联合感染的死亡率的风险因素和预测模型:一个回顾性队列研究
Yan Zhang1, Kailong Gu1, Wei Du1
1Department of Clinical Laboratory, Hangzhou Xixi Hospital, 2 Hengbu Road, Xihu District, 310023, Zhejiang, China.
Heliyon
|July 4, 2024
概括
晚年,高甲素 (PCT) 和高尿素与白蛋白比率 (UAR) 预测了人类免疫缺陷病毒 (HIV) 和Talaromyces marneffei (TM) 联合感染的患者的死亡率. 该模型有助于早期识别风险,以改善患者的治疗结果.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 同时感染人类免疫缺陷病毒 (HIV) 和Talaromyces marneffei (TM) 是一个重大的临床挑战,特别是在中国.
- 在这个人群中确定死亡风险因素对于及时干预和改善患者管理至关重要.
研究的目的:
- 确定与艾滋病毒和TM同时感染的患者的死亡相关的关键风险因素.
- 开发和验证HIV/TM同时感染患者死亡风险的预测模型.
主要方法:
- 对160名同时感染HIV/TM的患者 (2013-2024) 进行了回顾性队列分析.
- 后勤回归分析确定了死亡率的独立预测因素.
- 36名患者的验证队列使用曲线下的面积 (AUC) 评估预测模型的性能.
主要成果:
- 总体死亡率为17.35%. 这是一个很好的例子.
- 死亡的独立风险因素包括晚年 (OR: 1.103),高甲素 (PCT) 水平 (OR: 1.270),以及尿素与白蛋白比率 (UAR) 的增加 (OR: 1.491).
- 结合年龄,PCT和UAR的预测模型显示出高预测值 (验证组AUC=0.898).
结论:
- 高龄,PCT升高和UAR增加是HIV/TM同时感染患者死亡率的重要决定因素.
- 这些实验室参数可以作为早期死亡风险评估的有价值的预测指标.
- 开发的模型有助于及时识别和管理高风险个体.
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