大脑网络功能连接的变化 长期疾病持续时间 慢性精神分裂症 慢性精神分裂症
Yin Xia Bai1,2, Jia Xin Luo3,4, Duo Peng1,2
1Department of Psychiatry, Inner Mongolia Mental Health Center, Hohhot, China.
长期慢性精神分裂症 (10年以上) 显示大脑连接的改变. 特定的大脑区域的变化,比如在丘脑,可能表明精神分裂症患者的疾病持续时间延长.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 慢性精神分裂症的特征是大脑功能连接的广泛异常.
- 长期的疾病持续时间 (≥10年) 可能会呈现出明显的神经生物学变化.
研究的目的:
- 在长期疾病持续时间 (≥10年) 的慢性精神分裂症中识别特征性的功能和结构性大脑变化.
- 探索大脑网络功能连接和疾病持续时间之间的关系.
主要方法:
- 静止状态功能连接的独立组件分析 (ICA).
- 分析了六个静止状态网络 (听觉,默认模式,背部注意力,前额头,体运动,视觉).
- 与临床持续时间和接收器操作特征 (ROC) 曲线分析的相关性分析.
主要成果:
- 患有长期慢性精神分裂症的患者表现出增强的默认模式网络 (DMN) 网络间连接.
- 实体运动网络,DMN和视觉网络之间观察到网络间连接性减少.
- Cuneus_L中的功能性连接与疾病持续时间负相关; Thalamus_L, Rectus_L, Frontal_Mid_R和 Cerebelum_9_L的变化可能表明疾病持续时间较长.
结论:
- 慢性精神分裂症的疾病持续时间与特定大脑区域的变化有显著的关联.
- 观察到的功能连接性变化可以作为长期慢性精神分裂症 (≥10年) 的潜在生物标志物.
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