在伊巴丹的耐药结核病患者中血液学参数
Pelumi Daniel Adewole1,2, Tosin Deborah Ogundipe3, Olumuyiwa Samuel Alabi2
1Department of Medical Laboratory Science, College of Health Sciences, Bowen University, Iwo, Osun State, Nigeria.
African health sciences
|July 4, 2024
概括
与药物敏感结核病患者相比,在多抗药结核病 (DR-TB) 患者中观察到较低的血红蛋白水平,表明潜在的预后价值. 白细胞计数显示,两组之间没有显著差异.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 结核病研究 结核病研究
背景情况:
- 在结核病 (TB) 患者中经常观察到血液学异常.
- 关于多药耐药结核病 (DR-TB) 中这些异常的预后意义的数据有限.
- 这项研究调查了全血细胞计 (CBC) 参数与DR-TB之间的关系.
研究的目的:
- 确定CBC变量与耐药结核病之间的关联.
- 探索血液学参数作为DR-TB的预后标记物的潜力.
主要方法:
- 一项涉及90名成年人的比较研究:30名耐药结核病患者,30名耐药结核病患者和30名健康对照.
- 采集血液样本并使用Mindary-BG5380 5部分自动化血液分析仪进行分析.
- 人口数据是通过结构化问卷收集的.
主要成果:
- 与DS-TB患者 (8.33 ± 9.56 fL) 相比,DR-TB患者的平均血红蛋白水平显著较低 (11.70 ± 2.73 g/dL).
- 平均MCH和MCHC水平在DR-TB患者中略低,但没有统计学意义.
- 在DR-TB和DS-TB组中,白细胞 (WBC) 计数在DR-TB和DS-TB组之间相似.
结论:
- 在DR-TB患者中显著降低血红蛋白水平可能与DR-TB相关的炎症增加有关.
- 类似的白细胞计数表明DR-TB和DS-TB患者感染的免疫反应相似.
- 血液学参数,特别是血红蛋白,可以作为DR-TB的潜在预后指标.
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