非酒精性脂肪肝疾病作为2型糖尿病患者心血管疾病的潜在危险因素:一项前性队列研究

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An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

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Mohammad Dehghani Firouzabadi¹, Amirhossein Poopak¹, Ali Sheikhy^1,2

¹Endocrinology and Metabolism Research Center (EMRC) Vali-Asr Hospital Tehran University of Medical Sciences, Tehran, Iran.

International journal of endocrinology

|July 4, 2024

概括

非酒精性脂肪肝 (NAFLD) 在2型糖尿病 (T2D) 患者中显著增加心血管疾病 (CVD) 风险. 然而,肝酶水平在这个队列中与心血管疾病发病率没有显著的关联.

科学领域:

心脏病学心脏病学
肝病学肝病学是一种肝病学.
内分泌学在内分泌学.

背景情况:

非酒精性脂肪性肝病 (NAFLD) 是2型糖尿病 (T2D) 中常见的并发症.
越来越多地认为NAFLD是心血管疾病 (CVD) 的风险因素.

研究的目的:

调查NAFLD与T2D患者心血管疾病发病率之间的关联.
评估肝酶和阿斯巴达胺转移酶与血小板比率指数 (APRI) 在预测该人群中心血管疾病风险方面的作用.

主要方法:

一项前性队列研究涉及1197名T2D患者,分为NAFLD (360) 和非NAFLD (847) 组.
随访时间中位数为5年,以记录心血管疾病发病率.
考克斯回归分析以评估NAFLD,肝酶,APRI和心血管疾病风险之间的关联.

主要成果:

NAFLD与心血管疾病发病率的增加显著相关 (HR=1.488,p=0.029).
患有NAFLD的患者表现出更高的ALT和AST水平 (p<0.001).
在调整了变量后,没有发现肝酶 (ALT,AST) 和心血管疾病发病率之间的显著关联. NAFLD与较高的APRI四分位数存在关联.

结论:

NAFLD是T2D患者心血管疾病发病率增加的独立风险因素.
标准肝酶 (ALT,AST,ALK-P,GGT) 在调整为混因子时,与T2D患者的心血管疾病风险没有显著关联.

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