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克隆进化过程从基本血栓细胞血症到急性髓性白血病在原始患者中,从这些患者中建立了CALR突变的Marimo细胞系

Yoko Ushijima1, Yuichi Ishikawa1, Takahiro Nishiyama1,2

  • 1Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Nagoya journal of medical science
|July 4, 2024
PubMed
概括

马里莫细胞系的遗传分析显示,NRAS突变驱动精髓血栓塞瘤 (ET) 到急性髓性白血病 (AML) 的进展. 这种NRAS突变克隆的扩散导致了Marimo细胞系的建立,突出显示了MAPK通路的激活.

关键词:
这就是CALRR.马里莫细胞系的细胞系克隆的进化过程基本的血栓细胞血症.转化转化转化转化转化转化转化转化

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