维生素D状态与甲状腺癌之间的关联:一个元分析
Yue Hu1,2, Chongxiang Xue3,4, Shumeng Ren2
1Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in nutrition
|July 4, 2024
概括
这次元分析发现,较低的维生素D水平与较高的甲状腺癌 (TC) 风险有关. 维生素D缺乏增加了发展TC的可能性,突出了其在癌症发展中的潜在作用.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 越来越多的维生素D缺乏与各种癌症有关.
- 维生素D水平与甲状腺癌 (TC) 风险之间的特定关联仍然不清楚.
- 需要进行全面的元分析,以巩固有关维生素D和TC的现有证据.
研究的目的:
- 确定维生素D水平与患甲状腺癌 (TC) 的风险之间的关联.
- 量化与维生素D缺乏相关的TC风险.
- 探索维生素D水平和TC风险之间的剂量反应关系.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane,ClinicalTrials.gov) 进行系统的文献搜索.
- 对比维生素D水平和TC病例与对照病例中缺乏症发病率的研究的元分析.
- 包括标准化平均差异 (SMD),平均比率 (RoM),几率比率 (OR),剂量反应分析,子组分析和元回归.
主要成果:
- 与对照组相比,TC病例的维生素D水平显著降低 (SMD = -0.25,RoM = 0.87).
- 维生素D缺乏与TC风险增加有关 (OR=1.49).
- 一个剂量反应分析表明,每10 ng/ml降低25 ((OH) D水平时,TC风险增加6%.
结论:
- 患有甲状腺癌的个体表现出较低的维生素D水平.
- 维生素D缺乏是与甲状腺癌风险增加相关的重要危险因素.
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