化疗和放射治疗对早期喉癌的影响
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Updated: Jun 22, 2025

Learning Modern Laryngeal Surgery in a Dissection Laboratory
Published on: March 18, 2020
Ryouhei Akanabe1, Kiyoto Shiga1, Katsunori Katagiri1
1Department of Head and Neck Surgery, Iwate Medical University School of Medicine, Yahaba, Japan.
与多塞素的化疗放射治疗在II期喉平细胞癌 (SCC) 中提供了优异的结果,相比于仅用于I期SCC的放射治疗. 这种方法增强了局部控制和喉保护,并具有可控的副作用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
背景情况:
- 早期喉平细胞癌 (SCC) 可以通过放射治疗 (RT),化疗放射治疗 (CRT) 或手术治疗.
- 治疗策略根据瘤阶段而异,T1N0瘤通常接受RT,T2N0瘤接受CRT.
研究的目的:
- 为了比较RT与CRT与多塞 (DOC) 治疗早期喉SCC的疗效和治疗结果.
- 评估T1N0和T2N0喉SCC患者的生存率,局部控制和喉保存.
主要方法:
- 分析了78名早期喉SCC患者的队列.
- T1N0患者接受了门诊RT (63-70 Gy).
- T2N0患者接受住院CRT与同时服用多塞塔塞尔 (10 mg/m2每周6-8周) 和RT (66-70 Gy). 评估了不良事件,生存率和局部控制.
主要成果:
- 与T1N0患者相比,T2N0患者的3级不良事件 (粘膜炎,皮肤炎) 显著增加.
- 五年生存率是可比的:整体 (86.1%对比85.9%),疾病特异性 (93.3%对比88.0%).
- 两个组的局部控制率都很高 (88.6%对93.1%),喉的保存率很好 (94.3%对93.1%).
结论:
- 用多塞塔克塞尔进行化学放射治疗显示,T2N0喉SCC的治疗结果优越.
- 这种方法可以实现高度的局部控制和有效的喉保护.
- 与多塞塞尔的CRT是一种高度有效的治疗选择,用于晚期早期喉SCC.
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