艾滋病毒感染者病毒抑制的当前梅毒感染:中国东部的一项横截面研究
Lin He1, Xiaohong Pan1, Jiezhe Yang1
1Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
Frontiers in public health
|July 4, 2024
概括
在中国,感染艾滋病毒的人群中发现了高比例的当前梅毒感染. 抗逆转录病毒治疗 (ART) 的持续时间并没有降低梅毒的发病率,这凸显了对高风险群体进行有针对性的干预的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 抗逆转录病毒疗法 (ART) 有效抑制人类免疫缺陷病毒 (HIV) 复制,但其对梅毒等性传播感染 (STIs) 的影响尚不清楚.
- 了解病毒抑制个体中性传播感染的流行率对于全面的艾滋病毒管理和预防策略至关重要.
研究的目的:
- 确定在中国东部实现了病毒抑制的艾滋病毒感染者 (PLWH) 中目前梅毒感染的流行率.
- 调查ART的持续时间是否会影响病毒抑制的PLWH当前梅毒感染率.
主要方法:
- 2022年,在中国江省进行了一项横截面调查,其中包括30744名在ART治疗6个多月的PLWH,病毒载量<50副本/毫升.
- 数据来源于国家流行病学数据库;参与者接受病毒载量和梅毒测试.
- 多变量逻辑回归分析确定了与当前梅毒感染相关的风险因素.
主要成果:
- 该研究包括30744名参与者,其中5.6%的测试结果为当前梅毒阳性.
- 梅毒的重要风险因素包括男性,高等教育,同性恋艾滋病毒传播途径,非本地居住,以前的性病史和市立医院治疗.
- 结婚与梅毒感染风险降低有关.
结论:
- 目前,中国东部的大量病毒抑制的PLWH感染梅毒.
- 在这一群体中,ART的持续时间与梅毒发病率降低无关.
- 干预措施应量身定制,以应对高风险子组,以有效降低PLWH中梅毒率.
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