来自肠道的野生蓝的酸代谢物调节外部皮肤损伤
John Ivarsson1,2, Abby Bennett2, Francesca Ferrara3
1Department of Animal Science, Plants for Human Health Institute, NC Research Campus, NC State University, Kannapolis, NC 28081, USA. gvalacc@ncsu.edu.
Food & function
|July 4, 2024
概括
蓝中的类代谢物通过减少炎症和保存结构蛋白质来保护皮肤免受紫外线损伤. 这一发现突出了它们增强皮肤防御环境压力因素的潜力.
科学领域:
- 皮肤病学 皮肤病学
- 生物化学 生物化学
- 细胞生物学 细胞生物学
背景情况:
- 皮肤的自然防御系统可以对抗环境的氧化损伤.
- 保护皮肤免受过早衰老需要了解如何增强这些防御.
- 饮食化合物为增强皮肤保护机制提供了潜在的途径.
研究的目的:
- 研究五种食类代谢物对紫外线引起的皮肤损伤的保护作用.
- 在人体皮肤和内皮细胞的ex vivo共同培养模型中评估这些代谢物.
- 确定潜在的保护机制,包括减少氧化应激和炎症.
主要方法:
- 建立了一个使用人类皮肤扩展剂和初级内皮细胞的ex vivo共同培养模型.
- 皮肤开拓者被暴露在紫外线辐射中.
- 内皮细胞被预先处理了特定的类代谢物的生理度 (hippuric 酸,isoferulic 酸,salicylic 酸,酸,α-hydroxyhippuric 酸).
主要成果:
- 用代谢物预处理内皮细胞可以防止紫外线引起的皮肤损伤.
- 代谢物减少了皮肤脂质过氧化,炎症酶 (COX-2,NOX-4) 和炎症细胞因子 (IL-1β,IL-8).
- 通过对代谢物进行预处理,可以防止紫外线诱导的结构蛋白质 (involucrin,原1型) 和氧化应激标记物 (HO-1) 的损失.
结论:
- 饮食中的代谢物可以显著地保护皮肤免受紫外线引起的损伤.
- 这些代谢物通过减少氧化应激,炎症,并保留关键结构蛋白质来起作用.
- 这些发现支持了饮食中的多的潜力,可以增强对外部压力因素的皮肤防御能力.
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