相关实验视频

Updated: Jun 22, 2025

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

三只鸟用一块石头:铜离子辅助协同缩缩/化学动力学/光热疗法通过三方方法

Mengyao Chen¹, Chang Xu¹, Chunhui Wang¹

¹School of Chemical Science and Engineering, Department of Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Tongji University, Shanghai, 200092, P. R. China.

Advanced healthcare materials

|July 4, 2024

概括

这项研究引入了一种用于癌症治疗的新型铜离子调节器 (CuP-CL). CuP-CL结合了光热疗法 (PTT),化学动力疗法 (CDT) 和cuproptosis,有效地消除癌细胞.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

铜平衡对于细胞功能至关重要;不平衡会导致细胞死亡.
人工调节细胞铜提供了癌症治疗的策略.
开发利用瘤微环境特征的向疗法至关重要.

研究的目的:

开发一种新的铜离子稳态扰动器 (CuP-CL),用于增强癌症治疗.
研究光热疗法 (PTT),化学动力疗法 (CDT) 和cuproptosis的协同效应.
利用甲 (Cin) 和热敏脂质体用于向药物输送和瘤微环境调制.

主要方法:

用聚多巴胺,Cu2+,甲和热敏脂质体制造CuP-CL纳米颗粒.
激光照射以触发PTT和脂质体释放.
评估Cu2+释放及其在cuproptosis和CDT中的作用.
评估 cinnamaldehyde 在调节瘤微环境 (H2O2 供应,GSH 消耗) 的功能.
调查涉及ROS,LPO和HSP的积极反循环.

主要成果:

在激光曝光时,CuP-CL显示增强了PTT,触发了Cu2+和Cin的释放.
释放的Cu2+诱导了cuproptosis和CDT,由Cin.放大了.
PTT,CDT和cuproptosis的协同作用导致了显著的癌细胞死亡.
在体外和体内研究证实了CuP-CL的显著抗瘤性能.
积极的反机制提高了整体治疗结果.

结论:

CuP-CL代表了一种可行的多式模式癌症治疗策略.
PTT,CDT和cuproptosis的组合为癌症治疗提供了一个强大的方法.
有针对性的铜离子调节和瘤微环境调节在癌症治疗中是有效的.

关键词:

这就是cuproptosis.离子干扰离子干扰积极的反效应产生了积极的反效应.协同疗法是一种协同疗法.

更多相关视频

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

相关概念视频

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...