在哺乳动物新皮质中,当没有细胞架构上明显的第4层时,核心甲状腺皮质轴线在哪里结束?
Adhil Bhagwandin1, Zoltán Molnár2, Mads F Bertelsen3
1School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Republic of South Africa.
The Journal of comparative neurology
|July 4, 2024
概括
哺乳动物大脑皮层通常有六层,但在某些区域和物种中,第4层是不存在的或模糊的. 这项研究绘制了状皮层投影的地图,揭示了这些独特的皮层结构中的各种终结模式.
科学领域:
- 神经科学是一个神经科学.
- 比较解剖学的比较解剖学
- 进化生物学 进化生物学
背景情况:
- 哺乳动物大脑皮层通常被描述为一个六层结构.
- 然而,某些皮质区域和物种表现出不清晰或不存在的4层.
- 第4层通常接收来自核心皮层系统的皮层投射.
研究的目的:
- 在物种和缺乏明显层的皮质区域中研究核心 thalamocortical 投射的终点点 4.
- 为了了解不同哺乳动物大脑中甲状腺皮层输入模式的变化.
- 探索皮层组织中的第四层变异的进化影响.
主要方法:
- 使用囊泡性谷氨酸转运体2 (VGLUT2) 的免疫定位作为核心 thalamocortical轴突终端的标记物.
- 检查了31种eutherian哺乳动物物种,重点关注带有非典型层的皮质区域4.
- 分析了与细胞架构相关的终结模式.
主要成果:
- 在物种之间发现了4层存在的变化和皮层投射模式.
- 在/微类动物中,突出准了第1,4层和内3层.
- 在灵长类初级运动皮质中,投影在整个3层结束,没有明显的4层.
- 在大象,类动物和河马中,投射的目标是内外层3,缺乏明显的层4.
结论:
- 皮层4及其相关的甲状腺皮层投影显示了哺乳动物之间显著的差异.
- 这些变化与皮层处理和感知方面的差异相关.
- 模糊或缺席的第4层代表了皮层组织中的进化轨迹.
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