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的光激活抗癌活性 (III) 复合物与天然存在的黄酸 (chrysin) 和酸 (silibinin) 复合

Jyotirmoy Dutta¹, Arpan Bera², Aarti Upadhyay²

¹Department of Chemistry, Handique Girls' College, Guwahati, Assam, 781001, India.

Chembiochem : a European journal of chemical biology

|July 4, 2024

概括

新的 (III) 复合物与天然黄化合物显示出对癌症光动力学治疗 (PDT) 的前景. 复合物Co5和Co6有效地向癌细胞,对正常细胞的毒性最小,通过单片氧生成诱导细胞亡.

科学领域:

协调化学协调化学
光动力学疗法光动力学疗法
癌症研究癌症研究

背景情况:

使用生物必需的过渡金属和天然化剂的光活性金属复合物正在成为癌症光动力疗法 (PDT) 的光细胞毒剂.
开发具有增强疗效和选择性的新型综合体对于推进PDT应用至关重要.

研究的目的:

合成和表征六种新的 (III) 复合物,其中含有天然黄的混合合物配方.
评估这些复杂物对癌细胞的光细胞毒性,稳定性和作用机制.

主要方法:

六个 (III) 复合物的合成 ([CoB2L]ClO4) 2) 与N,N-捐赠者α-二胺联体 (phen,dpq,dppz) 和天然黄 (chrysin,silibinin).
用光谱分析 (UV-Vis) 来确定吸收波段 (500-700 nm).
在可见光照射下对HeLa和A549癌细胞和HPL1D正常细胞进行细胞毒性测定 (IC50值).
流细胞计和ROS生成试验以阐明细胞死亡机制.

主要成果:

复合物Co5和Co6,包括二氧化和黄联体,对宫 (HeLa) 和肺 (A549) 癌细胞表现出显著的光细胞毒性 (IC50:2.3-3.4μM).
这些复合体对正常的肺上皮细胞 (HPL1D) 具有低毒性.
光动力学作用涉及诱导亡和在可见光照射后单点氧气生成.

结论:

(III) 复合物Co5和Co6表现出极好的光细胞毒性活性和选择性,使它们成为癌症光动力学治疗的有希望的候选者.
天然的黄类和二氧化类联体有助于增强这些金属复合物的治疗潜力.

关键词:

细胞亡癌症 (((III) 黄类物质光动力学疗法

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