核桃花和其与西斯普拉丁的组合:通过调节亡基因来作为潜在的抗癌候选物
Soudeh Khanamani Falahati-Pour1, Seyedeh Atekeh Torabizadeh2,3, Fatemeh Baghery1
1Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Anti-cancer agents in medicinal chemistry
|July 4, 2024
概括
pistachio 提取物 (PPE 和 PKE) 与西斯普拉丁结合,对前列腺癌细胞表现出强大的抗癌作用. 这些天然化合物通过改变关键基因表达来协同抑制癌细胞的增殖.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 生物活性植物化学物质对于疾病管理和药物开发至关重要.
- 前列腺癌 (PCa) 治疗需要新的治疗策略.
研究的目的:
- 为了评估 pistachio 皮卡皮提取物 (PPE) 和 pistachio 核提取物 (PKE) 的抗瘤功效.
- 在前列腺癌治疗中研究PPE和PKE与西斯 (CP) 的协同作用.
- 阐明底层的分子作用机制.
主要方法:
- 用PPE,PKE和CP单独和组合治疗PC-3前列腺癌细胞.
- 用MTT测定来评估细胞增殖.
- 基因表达分析 (BAX,BCL-2,P53,KL2,TNF,TGF,NANOG) 使用实时PCR进行.
主要成果:
- 组合的PPE+CP和PKE+CP治疗表现出比单独的治疗方法显著更大的抗繁殖效应.
- 在实验室中观察到协同抗增殖活性,在组合疗法中降低了IC50值.
- 治疗调节了mRNA表达,增加了BAX和P53,同时降低了BCL-2,KLK2,TNF,TGF和NANOG.
结论:
- 个人防护品和人体肌肉蛋白对PC-3细胞具有抗癌效应,无论是独立使用还是与CP结合使用.
- 这些发现突显了 pistachio 提取物在前列腺癌治疗中作为辅助剂的潜力.
- 这项研究为开发草药抗癌药物提供了基础.
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