在儿童和成年人的草药与亚托匹性皮肤炎:一个系统的审查和元分析
Melanie Anheyer1,2, Holger Cramer3,4, Thomas Ostermann5
1From the Department for Pediatric and Adolescent Medicine, Elisabeth Hospital Essen, Essen, Germany.
Dermatitis : contact, atopic, occupational, drug
|July 4, 2024
概括
这项系统性审查发现,一些局部草药对亚托邦性皮炎有效,但系统性晚油对安慰剂没有显著的益处. 需要对草药药物进行更严格的研究.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 基于证据的医学 基于证据的医学
背景情况:
- 草药经常用于皮肤病,包括亚托邦性皮肤炎.
- 需要进行系统审查,以评估草药干预措施对阿托皮性皮肤炎的疗效.
研究的目的:
- 系统地审查随机对照试验 (RCT) 关于局部和全身草药干预对亚托皮炎的疗效.
- 评估证据的质量,并确定有希望的草药治疗方法.
主要方法:
- 在MEDLINE/PubMed,Scopus和Cochrane中央注册表中进行全面的文献搜索 (截至2023年4月12日).
- 包括RCT,数据提取和使用Cochrane偏差风险工具进行质量评估 2.0.0.
- 使用随机效应模型的元分析和出版偏差的评估.
主要成果:
- 包括51个RCT (3763名参与者),调查了19种草药和5种复杂疗法.
- 草药的局部应用,如向日,甘草和天然,显示出有效性的证据.
- 与安慰剂相比,全身晚油 (EPO) 在13个RCT的元分析中没有显示出与安慰剂相比,亚托皮炎严重程度的显著改善.
结论:
- 个别的局部草药制剂在治疗亚托皮性皮炎方面表现有前途.
- 系统性晚上灵花油缺乏证明了超过安慰剂的有效性.
- 需要进行更大,更高质量的研究来证实草药治疗亚托皮炎的有效性.
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