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在过重和肥胖儿童的生活方式干预期间评估功能估计的评估
Mark J C M van Dam1, Hans Pottel2, Pierre Delanaye3,4
1Centre for Overweight Adolescent and Children's Healthcare (COACH), Department of Pediatrics, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center +, MosaKids Children's Hospital, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands. mark.van.dam@mumc.nl.
Pediatric nephrology (Berlin, Germany)
|July 4, 2024
概括
针对儿童肥胖的生活方式干预显示了重新缩放的血清肌素 (SCr/Q) 略微增加,表明估计的功能略有下降. 这种变化似乎独立于BMIz-score的减少.
科学领域:
- 儿科脏病学 儿科脏病学
- 肥胖医学 肥胖医学
- 临床试验 临床试验
背景情况:
- 超重和肥胖儿童面临慢性病 (CKD) 的风险增加.
- 生活方式干预是儿童肥胖的主要治疗方法,涉及身体比例的变化.
- 这项研究调查了生活方式干预对肥胖儿童功能估计的影响.
研究的目的:
- 评估生活方式干预对超重和肥胖儿童基于肌素的功能估计的影响.
- 为了确定干预期间身体组成的变化是否与功能标志物相关.
主要方法:
- 一项纵向的生活方式干预研究包括614名超重/肥胖儿童 (平均年龄12.17岁).
- 用Q-年龄和Q-高度多项数来估计功能,重新调整血清肌素 (SCr).
- 用线性混合回归分析了数据,考虑到对随访的重大损失.
主要成果:
- 在基线时,大多数儿童的SCr/Q值正常 (0.67-1.33).
- 在干预期间,每年SCr/Q显著增加,这表明估计功能略有下降 (每次访问每次EGFRFAS减少1.1-4.1mL/min/1.73m2).
- 体重指数z-score下降,特别是在男性中,但与重新缩放的SCr.的变化没有相关性.
结论:
- 肥胖儿童的多学科生活方式干预导致血清肌氨酸 (SCr/Q) 略微增加.
- 这种观察到的功能估计的变化是独立于BMIz-score的减少.
- 这种小额估计的功能下降的长期临床意义需要在扩展后续研究中进一步调查.
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