相关实验视频
Updated: Jun 22, 2025
08:50
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
6.9K
基于新陈代谢的预测得分对老年患者的死亡率的表现 固体瘤患者的死亡率
Yara van Holstein1, Simon P Mooijaart2,3, Mathijs van Oevelen4
1Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, PO box 9600, 2300 RC, Leiden, The Netherlands. Y.van_Holstein@lumc.nl.
GeroScience
|July 4, 2024
概括
基于代谢学的分数,MetaboHealth和MetaboAge,预测老年癌症患者的1年死亡率. 当MetaboHealth被添加到临床因素中时,它显示出识别易受伤害的患者的潜力.
科学领域:
- 老年瘤学 老年瘤学
- 代谢学 代谢学 代谢学
- 预测生物标志物 预测生物标志物
背景情况:
- 准确的预后信息对于优化老年患者癌症治疗决策至关重要.
- 基于代谢学得分,MetaboHealth和MetaboAge,以前预测的长期死亡率和生物年龄.
研究的目的:
- 评估代谢健康和代谢年龄与有固体瘤的老年人1年死亡率的关联.
- 评估这些代谢学评分的附加预测价值与已建立的临床预测死亡率.
主要方法:
- 对192名年龄≥70岁,有固体瘤的患者进行前性队列研究.
- 在开始治疗之前收集了血液样本和老年评估.
- 所有原因的1年死亡率是主要结局.
主要成果:
- 较高的MetaboHealth和MetaboAge分数与1年死亡风险的增加有显著关联.
- 代谢健康 (HR 2.32) 和代谢年龄 (HR 1.04) 显示出独立的预测价值.
- 将MetaboHealth添加到临床模型中略有改善了死亡率预测 (AUC为0.80对0.76),而MetaboAge则没有.
结论:
- 代谢健康和代谢年龄与老年癌症患者的1年死亡率有关.
- "MetaboHealth"可能有潜力用于识别患有不良结果风险较高的老年患者.
- 需要对更大的队列进行进一步的研究,以确认这些代谢分数的临床效用.
相关概念视频
01:21Cancer Survival Analysis
340
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
340
01:24Kaplan-Meier Approach
123
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
123