在糖尿病前期的OGTT期间不充分抑制葡萄糖:系统性审查和元分析
Lina Chang1, Ying Liu1, Yian Gu1
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China.
The Journal of clinical endocrinology and metabolism
|July 4, 2024
概括
在糖尿病前期 (preDM),葡萄糖水平在摄入葡萄糖后没有得到充分的抑制. 这种葡萄糖调节失调是导致快食葡萄糖受损 (IFG) 和葡萄糖耐受性受损 (IGT) 的关键因素.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究 糖尿病研究
背景情况:
- 葡萄糖在2型糖尿病中的作用已确立,但其在糖尿病前期 (糖尿病前期) 的功能尚未完全理解.
- 糖尿病前期代表了一个关键的窗口,以了解2型糖尿病的进展.
研究的目的:
- 进行元分析,评估禁食葡萄糖水平及其在糖尿病前期对葡萄糖的抑制反应.
- 为了澄清葡萄糖失调在不同糖尿病前表型中的作用.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行系统的文献搜索.
- 在糖尿病前期和正常葡萄糖耐受性 (NGT) 队列中,在口服葡萄糖耐受性测试 (OGTT) 中测量葡萄糖,葡萄糖和胰岛素的研究.
- 用于数据聚合的随机效应模型.
主要成果:
- 与NGT相比,在OGTT期间,糖尿病前患者在多个时间点表现出显著更高的葡萄糖水平,尽管葡萄糖和胰岛素水平升高.
- 禁食葡萄糖在降低葡萄糖耐受性 (IGT) 和降低禁食葡萄糖 (IFG) 两种情况下都被不充分抑制.
- 葡萄糖抑制对葡萄糖抑制的葡萄糖抑制反应在IFG中保留,但在IGT中没有.
结论:
- 在患有糖尿病前期的个体中,在OGTT期间,葡萄糖被不充分抑制.
- 葡萄糖调节失调被确定为IFG和IGT的贡献机制,强调其在糖尿病前期进展中的重要性.
相关概念视频
Hypoglycemia and Glucagon
254
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
254
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Hormones Regulating Blood Glucose
3.2K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
3.2K
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Oral Hypoglycemic Agents: Glinides
152
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
152
Glucose Homeostasis: Regulation of Blood Glucose
1.6K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.6K


