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在COVID-19后的患者中,循环calprotectin作为持久性嗅觉功能障碍的潜在生物标志物

Beatrice Francavilla¹, Gianluca Velletrani¹, Denise Fiorelli²

¹Department of Otorhinolaryngology, University of Rome "Tor Vergata", Rome 00133 Italy.

|July 4, 2024

概括

循环中的calprotectin (cCLP) 显示为持续的COVID-19后嗅觉功能障碍的生物标志物. 随着嗅觉训练,水平下降,这表明它在监测治疗有效性的作用.

科学领域:

免疫学免疫学免疫学
生物标志物生物标志物
传染病研究传染病研究

背景情况:

持续的嗅觉功能障碍是COVID-19的常见后果.
目前正在研究循环蛋白 (cCLP) 作为潜在的炎症状况生物标志物.

研究的目的:

评估循环中的calprotectin作为COVID-19后持续嗅觉功能障碍的生物标志物.
为了评估嗅觉训练后calprotectin水平的变化.

主要方法:

一项纵向研究涉及36名患有COVID-19后嗅觉功能障碍 (低/低) 的患者和两个对照组.
在3个月的嗅觉训练之前和之后测量血清和鼻子上游生物calprotectin水平.
在患者和对照组之间比较calprotectin水平,并评估干预后的变化.

主要成果:

与对照人群相比,患有嗅觉功能障碍的患者的血清和鼻中发现了较高的calprotectin水平.
嗅觉训练后观察到嗅觉功能的显著改善.
在训练后的血清和鼻腔样本中,观察到相应的calprotectin水平下降.

结论:

循环中的calprotectin显示出作为COVID-19后持续性嗅觉功能障碍的生物标志物的潜力.
减少calprotectin水平表明其在监测嗅觉障碍治疗反应中的有用性.
需要进一步的研究来验证鼻子疾病中的calprotectin测定及其与鼻腔细胞学的相关性.

关键词:

在 Calprotectin 中使用.缺血症是什么意思缺血症是什么意思长时间的COVID.鼻子刷子鼻子刷子嗅觉是一种嗅觉.嗅觉培训嗅觉培训嗅觉培训

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