在新型治疗方式时代,多发性骨髓瘤和感染
Mobil Akhmedov1, Pervin Zeynalova2, Alexander Fedenko3
1Department of High-dose Chemotherapy and Bone Marrow Transplantation, P.A. Herzen Moscow Oncology Research Institute, branch of the National Medical Radiology Research Center, Russian Federation; Department of Oncology and Oncosurgery, Russian University of Medicine, Russian Federation.
患有多发性骨髓瘤的患者面临来自各种治疗方法,包括新型治疗方法的重大感染风险. 本综述详细介绍了接受多种治疗的多发性骨髓瘤 (MM) 患者的感染模式和预防策略.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 感染是多发性骨髓瘤 (MM) 患者发病和死亡的主要原因.
- 目前的MM治疗,包括化疗,免疫疗法和移植,都与明显的传染性并发症有关.
- 新兴的疗法,如双特异性T细胞参与剂和CAR T-淋巴细胞引入新的感染风险.
研究的目的:
- 审查多发性骨髓瘤患者在不同治疗阶段的发病率,风险因素和感染模式.
- 要总结与复发性耐药MM的新疗法相关的传染性并发症.
- 为MM患者提供基于证据的见解,了解当前的传染病预防策略.
主要方法:
- 对多发性骨髓瘤感染研究的综合文献综述.
- 对治疗方案的分析,包括蛋白酶体抑制剂,免疫调节药物,单克隆抗体,移植,双特异性T细胞参与剂和CAR T-淋巴细胞.
- 综合有关感染发生率,风险因素,模式和预防的数据.
主要成果:
- 不同的MM治疗方法会产生特定的感染风险和模式.
- 造血细胞移植和新型药物带来了复杂的传染性挑战.
- 了解这些模式对于有效的预防至关重要.
结论:
- 在多发性骨髓瘤治疗过程中,感染性并发症是关键问题.
- 量身定制的预防策略是必不可少的,特别是在新的治疗药物.
- 需要进一步的研究,以优化感染预防在不断变化的MM治疗景观.
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