用酸盐增强的双网水凝的机械和生物行为与凝的机械和生物行为
Alaa Ajam1, Yuwan Huang1, Md Shariful Islam2
1School of Mechanical and Manufacturing Engineering, University of New South Wales (UNSW Sydney), Sydney, NSW, 2052, Australia.
概括
凝增强聚乙烯甘醇 (PEG) 双网 (DN) 水凝的强度和刚度超过酸盐,从而提高伸展性. 这种比较指导了组织工程和软机器人的生物材料设计.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 组织工程是组织工程.
背景情况:
- 基于聚乙烯甘醇 (PEG) 的双网 (DN) 水凝对生物医学应用有前景.
- 酸和酸被用作DN水凝中的强化剂.
- 缺乏对它们对机械和生物特性影响的直接比较.
研究的目的:
- 为了比较PEGDMA DN水凝增强的机械和生物特性与酸相比,用酸加强了PEGDMA DN水凝.
- 调查增强剂类型对水凝强度,刚性,性和伸展性的影响.
- 为了评估细胞对这些独特的DN水凝系统的反应.
主要方法:
- 制造PEGDMA DN水凝,含有不同度的PEGDMA (10-20%重量) 和增强剂 (1-2%重量).
- 机械测试,包括破裂的未划分工作和划分的断裂性.
- 细胞培养研究评估附着,扩散和YAP核表达.
主要成果:
- 与阿尔金酸盐相比,格兰显著增加了PEGDMA DN水凝的强度,刚度和性.
- 酸盐强化导致PEGDMA DN水凝的伸展性更大.
- 这两种水凝都支持细胞的附着和扩散,在更硬的凝-PEGDMA水凝上,YAP表达更高.
结论:
- 格兰在增强PEGDMA DN水凝的强度和刚性方面优越.
- 阿尔金提供了更好的伸展性,提供了设计灵活性.
- 应仔细选择机械测试方法,以充分描述坚固的水凝系统.
- 这些发现为设计用于特定生物医学应用的DN水凝提供了关键的见解.
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