隐藏的联系:口腔和呼吸道微生物如何影响多发性硬化症
Melika Jameie1, Bahareh Ahli2, Sara Ghadir3
1Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Multiple sclerosis and related disorders
|July 4, 2024
概括
改变的口腔和呼吸道微生物组与多发性硬化症 (MS) 有关. 口腔和鼻子中的特定细菌变化可能会影响多发性硬化症的风险和症状,这表明新的治疗途径.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 在多发性硬化症 (MS) 中肠道微生物群的研究广泛.
- 口腔和呼吸道微生物群落在MS中的作用是一个新兴领域.
研究的目的:
- 审查有关患有多发性硬化症 (PwMS) 患者鼻腔,口腔和肺部微生物群的当前文献.
主要方法:
- 在PubMed. 进行了对原始研究的叙述性审查.
- 在审查的参考清单中搜索相关研究,并包括研究.
主要成果:
- 审查了13项研究:8项针对口服,3项针对鼻腔,2项针对肺部微生物群.
- 与健康对照组 (HCs) 相比,PwMS口腔和呼吸道微生物组的显著变化.
- 在PwMS中,特定的细菌属 (如Staphylococcus,Fusobacterium) 较为丰富,而其他细菌 (如Aggregatibacter,Streptococcus) 的数量较少.
结论:
- 在PwMS中口腔和鼻腔微生物组的变化可能会影响MS的发病 (例如,爱斯坦-巴尔病毒的重新激活,金黄色杆菌毒素).
- 在动物模型中,肺微生物组调节显示了抑制多发性硬化症症状的潜力.
- 进一步的研究对于了解微生物组-MS相互作用对于治疗开发至关重要.
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