晚期生殖与延长女性生存率有关,但与家族长寿无关
Annelien C de Kat1, Femke Roelofs2, P Eline Slagboom3
1Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands..
Reproductive biomedicine online
|July 4, 2024
概括
最后一次分娩的晚年年龄与女性寿命的延长有关. 然而,家族长寿似乎与最后一个孩子的年龄等生殖健康指标没有关联.
科学领域:
- 生殖健康 生殖健康
- 长寿研究 长寿研究
- 人类寿命研究研究
背景情况:
- 妇女的生殖健康,包括最后一次分娩的年龄和孩子的数量,是生殖成功的关键指标.
- 了解生殖因素与寿命之间的关系对于公共卫生和衰老研究至关重要.
研究的目的:
- 调查最后一次分娩时的年龄和儿童数量与个人寿命之间的关联.
- 检查女性生殖健康指标与家庭寿命之间的关系.
- 探索与家族寿命相关的更年期年龄的遗传倾向.
主要方法:
- 使用两个队列的观察性研究:与10,255名女性进行历史家庭重建的LINKing系统 (LINKS) 和与1,258名来自长寿家庭的女性进行的莱顿长寿研究 (LLS).
- 使用LINKS数据集分析最后一次分娩时的年龄和与个人和家庭长寿相关的儿童数量.
- 对更年期年龄的多基因风险评分 (PRS) 的评估及其与LLS数据集中的家族长寿的关联.
主要成果:
- 最后一次分娩时的年龄每年增加都与寿命增加0.06年有关 (P=0.002).
- 在他们的出生队伍中,最年长的10%的妇女每年有9%的最后一个孩子的风险较低 (危险比率为0.91).
- 在家族长寿与最后一次分娩的平均年龄或在更年期年龄的遗传倾向之间没有发现显著的关联.
结论:
- 女性生殖健康,特别是最后一次分娩时的晚年,与更长的个体寿命有关.
- 家庭长寿与延长生殖健康没有显著的关联.
- 其他影响体质维持的因素可能在确定寿命和生殖健康方面发挥作用.
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