病例系列:免疫抑制患者中的微细菌 aurum 细菌病 - - 新兴威胁
Gerlin Varghese1, Deepika Sarawat1, Ashima Jamwal1
1Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
概括
由Microbacterium aurum引起的血液感染在人类中很罕见. 这个案例系列突出了免疫抑制和内置导管等危险因素,展示了这种病原体首次记录的细菌病例.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 临床医学 临床医学
背景情况:
- 由于微细菌物种的血液感染 (BSI) 在人类中不常见.
- 微细菌光 (M. aurum) 感染通常与免疫抑制 (例如,化疗,皮质类固醇) 和内置导管有关.
- 关于M. aurum在引起细菌血症方面的病原性潜力存在有限的数据.
研究的目的:
- 报告第一个由M. aurum引起的细菌病例系列.
- 描述与M. aurum bacteremia相关的临床表现和风险因素.
- 为了评估M. aurum分离物的抗微生物敏感性模式.
主要方法:
- 三名患有M. aurum bacteremia的患者的回顾性病例系列.
- 使用矩阵辅助激光吸附离子化-飞行质谱时间 (MALDI-TOF MS) 识别M. aurum.
- 分析患者的风险因素,临床过程和抗菌素敏感性.
主要成果:
- 三名患者出现了M. aurum细菌血症.
- 确定的危险因素包括静脉导管 (血液透析,急性淋巴细胞白血病的化疗) 和免疫抑制 (类风湿性关节炎治疗).
- 根据敏感性报告,所有隔离物都得到了成功治疗,患者在稳定状态下出院.
结论:
- 这项研究代表了首次记录的M. aurum bacteremia病例.
- M. aurum可以引起血液感染,特别是在免疫功能低下的患者和内置设备中.
- 以敏感性测试为指导的抗微生物管理对M. aurum bacteremia.有效.
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