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由HKU1季节性冠状病毒激活和识别TMPRSS2的结构基础

Ignacio Fernández1, Nell Saunders2, Stéphane Duquerroy3

  • 1Institut Pasteur, Université de Paris Cité, CNRS UMR 3569, Structural Virology Unit, 75015 Paris, France.

Cell
|July 4, 2024
PubMed
概括

人类冠状病毒HKU1使用跨膜血清蛋白酶2 (TMPRSS2) 进入细胞. 结构研究揭示了关键的相互作用和宿主热带性决定因素,为病毒进入机制提供了洞察力.

关键词:
三维结构TMPRSS2 的抑制基调控蛋白质酶输入接收器人类冠状病毒血清蛋白酶激活峰值成熟时间病毒进入齐摩根三元组

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