与家族病史相关的卵巢癌风险因素
Guoqiao Zheng1, Louise Baandrup1,2,3, Jiangrong Wang4
1Unit of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen, Denmark.
Journal of the National Cancer Institute
|July 4, 2024
概括
卵巢癌风险因素,如平价和口服避孕药的使用,对有和没有家族病史的女性表现出类似的保护作用. 然而,子宫内膜异位症和子宫内膜异位症对那些有家族病史的人来说,风险更高.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 具有乳腺和/或卵巢癌家族病史的女性患卵巢癌的风险较高.
- 目前尚不清楚常见的卵巢癌风险因素是否会像一般人群一样影响这个高风险群体.
研究的目的:
- 调查常见的卵巢癌风险因素是否会影响有家族病史的女性与没有家族病史的女性相似.
- 在高风险人群中评估风险因素和卵巢癌之间的组织学特定关联.
主要方法:
- 利用丹麦和瑞典的全国性登记册建立了两个嵌套的病例控制研究群体.
- 包括有或没有乳腺和/或卵巢癌家族病史的妇女,分析了2138例卵巢癌病例和高风险组的85,240例对照.
- 使用条件后勤回归来评估整体和组织学特定的关联,结合国家特定的估计.
主要成果:
- 多种性,子宫切除术,输卵管绑定,切除术和口服避孕药 (OC) 的使用与两组的卵巢癌风险降低有关.
- 子宫内膜异位症和更年期激素治疗与风险增加有关.
- 多对性和OC使用的保护作用扩展到大多数组织学亚型,除了乳腺卵巢癌的例外. 更年期荷尔蒙疗法根据组织学表现出各种效果,而子宫内膜异位症与子宫内膜状细胞和透明细胞卵巢癌的相关性更强.
结论:
- 卵巢癌风险降低的危险因素在有和没有家族病史的妇女之间似乎是一致的.
- 由于基线风险较高,子宫内膜异位症和子宫内膜异位症在有家族病史的妇女中作为风险因素需要特别注意.
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