作为一种新的口服儿科输送系统,超分子尤特格尔可提高本兹尼达的生物可用性
Beatrice Albertini1, Serena Bertoni1, Giorgia Nucci1
1Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, I-40127 Bologna, Italy.
International journal of pharmaceutics
|July 4, 2024
概括
一种新型的高分子尤特格尔 (EG) 输送系统增强了Benznidazole (BNZ) 的口服生物可用性,这是查加斯病的关键治疗方法. 这种适合儿童的配方可以改善外围和中央系统的药物吸收.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 本津醇 (BNZ) 对于治疗夏加斯病至关重要,但其口服生物利用性较差.
- 现有的配方可能不适合小儿治疗.
研究的目的:
- 开发一个儿童友好的,口服输送平台,用于本兹尼达 (BNZ).
- 为了提高BNZ的口服生物可用性,使用了超分子尤特基凝 (EGs).
主要方法:
- 配制含有药物的天然深层乳清溶剂 (NaDES) 配合香糖 (XG) 和水,以制造乳清溶剂 (EG).
- 使用rheology和低场核磁共振 (NMR) 进行EGs的表征.
- 在体外评估稀释后的BNZ释放和超和.
- 在口服EGs后在老鼠体内药理动力学研究.
主要成果:
- 稳定,生物相容的5毫克/毫升的BNZ装载EGs成功地使用基于胆化物的NaDES和香丹制备.
- EGs表现出具有温度独立特征的粘弹性特性.
- 试验室研究表明,在稀释后BNZ超和,促进吸收.
- 在老鼠中,口服EGs导致BNZ在血和脑脊液中的生物可用性增加了2.6倍.
结论:
- 高分子欧特基凝为改善本津醇口服生物可用性提供了可持续和有效的平台.
- 该EG配方增强了外周和中枢神经系统的药物暴露.
- 这种儿童友好型的分娩系统有望改善查加斯病治疗的坚持和有效性.
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