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开发转录基因特征作为细胞衰老的生物标志物
Shamsed Mahmud1, Louise E Pitcher2, Elijah Torbenson1
1Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, 420 Washington Avenue SE, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Twin Cities, 420 Washington Avenue SE, Minneapolis, MN 55455, USA.
Ageing research reviews
|July 4, 2024
概括
细胞衰老,一种由压力引起的细胞周期退出,通过其炎症性SASP促进衰老和疾病. 转录组签名为在体内识别这些异质细胞提供了潜在的生物标志物.
科学领域:
- 细胞和分子生物学 细胞和分子生物学
- 衰老研究研究 衰老研究
- 生物标志物发现发现
背景情况:
- 细胞衰老是一种不可逆转的细胞循环停止状态,由各种压力因素引发.
- 衰老细胞可以发展出与衰老相关的分泌表型 (SASP),导致衰老和疾病.
- 在体内识别衰老细胞是具有挑战性的,因为它们的异质性和缺乏通用生物标志物.
研究的目的:
- 审查当前关于细胞衰老的转录组签名的知识.
- 探索这些特征作为体内生物标记物的潜力.
- 了解推动细胞衰老的遗传途径.
主要方法:
- 对衰老细胞的转录特征的分析.
- 识别特征基因组 (例如,细胞年龄,SeneQuest,SenMayo) 的识别.
- 单细胞和空间RNA测序的应用.
- 开发机器学习算法 (如 SenPred, SenSig, SenCID) 用于衰老的发现.
主要成果:
- 转录组分析已经确定了与细胞衰老相关的不同的基因组.
- 先进的测序和机器学习使研究衰老细胞异质性的研究成为可能.
- 这些方法促进了对衰老细胞的新型,可量化的生物标志物的发现.
结论:
- 转录组签名代表了在体内识别衰老细胞的有希望的途径.
- 了解这些签名可以更深入地了解衰老驱动的衰老和疾病.
- 转录基因生物标志物的进一步开发可能会彻底改变衰老研究和治疗策略.
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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...