相关实验视频

Updated: Jun 22, 2025

Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation

Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation

Published on: May 12, 2014

胺类迷幻药对感知扭曲和早期视觉皮层人口感受领域的快速影响

Marta Lapo Pais¹, Marta Teixeira¹, Carla Soares¹

¹Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Portugal; Institute of Nuclear Sciences Applied to Health (ICNAS), Portugal.

|July 4, 2024

概括

N,N-二甲基三胺 (DMT) 显著扩大视觉皮层的受体场,改变了外周视力. 这项神经成像研究揭示了DMT如何影响视觉感知和神经处理.

科学领域:

神经科学是一个神经科学.
视觉感知视觉感知视觉感知
心理药理学心理药理学

背景情况:

N,N-二甲基三胺 (DMT) 是一种已知会导致视觉感知发生深刻变化的迷幻化合物.
这些视觉效应背后的精确神经机制,特别是视觉空间的变化,仍然在很大程度上未被探索.
血清素5-HT2A受体激活与DMT的作用有关.

研究的目的:

调查DMT诱导的视觉感知变化的神经支.
测试这一假设,即在主要视觉皮层 (V1) 中的人口受体场 (pRF) 属性的变化调解了这些效应.
探索DMT,pRF变化和主观视觉扭曲之间的关系.

主要方法:

在主体内设计中利用磁共振成像 (MRI).
采用pRF映射来测量神经群体视觉响应特性和早期视觉区域的视网膜图.
使用幻觉评分表 (HRS) 量化主观视觉效应.

主要成果:

与对照组相比,在活性DMT条件下,在V1的外周视野中观察到平均pRF大小的显著增加.
病情之间没有检测到眼睛或头部运动的显著差异.
观察到的pRF变化与对视觉效应的主观报告相关.

结论:

短期服用DMT会导致主要视觉皮层内的pRF大小发生可测量的变化.
这些V1 pRF属性的变化为幻觉诱导的视觉扭曲,如场模糊和道视觉等提供了潜在的神经解释.
这些发现支持了一个模型,其中5-HT2A受体激活调节视觉皮层活动,影响知觉体验.

关键词:

5-HT2A受体是一种人口的反应.迷幻药物是一种精神药物.这是一种血清胺.视觉皮层的视觉皮层.视觉幻觉视觉幻觉是一种幻觉.

更多相关视频

Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography

Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography

Published on: July 26, 2019

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

Published on: April 1, 2010

相关概念视频

Hallucinogens and Psychedelics

Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...

CNS Stimulants: Psychedelic Agents

CNS Stimulants: Psychedelic Agents

Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...

Altered States of Awareness

Altered States of Awareness

Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...