在冠状动脉绕道手术后,性别特定的热素和肌酸激酶值
Leo Pölzl1, Matthias Thielmann2, Philipp Sterzinger3
1Department of Cardiac Surgery, Medical University of Innsbruck, Austria.
The Annals of thoracic surgery
|July 4, 2024
概括
在冠状动脉旁路移植 (CABG) 后心脏生物标志物释放的性别特异性影响患者的结果. 制定心脏素 (cTn) 和肌肉激酶-心肌带 (CK-MB) 的性别特定值对于准确的诊断和改善护理至关重要.
科学领域:
- 心脏病学 心脏病学
- 生物标志物研究 生物标志物研究
- 医学中的性别差异.
背景情况:
- 性别对冠状动脉旁路移植 (CABG) 后心脏生物标志物释放的影响尚不清楚.
- 心脏生物标志物,如高灵敏性心脏素 (hs-cTn) 和肌肉激酶-心肌带 (CK-MB),对于评估心肌损伤至关重要.
研究的目的:
- 为了研究CABG后心脏生物标志物释放的性别差异.
- 确定hs-cTn和CK-MB的性别特异性值,以预测30天的主要心血管不良事件 (MACE) 和死亡率.
主要方法:
- 在2008年至2021年期间,对3687名患者 (643名女性,3044名男性) 进行CABG的队列分析.
- 系列术后测量hs-cTn和CK-MB.
- 确定与30天MACE和死亡率相关的生物标志物的性别特定值.
主要成果:
- 与男性相比,女性在CABG后的hs-cTn释放量较低 (69.18比77.57倍以上的上限).
- 预测30天MACE的最佳hs-cTn值是女性的URL的94.36倍,男性的URL的206.07倍.
- 根据一般值评估的女性患者显示,MACE和30天内死亡的风险增加.
结论:
- 在心脏生物标志物释放和CABG后的结果中存在显著的性别特异.
- 心脏生物标志物的性别特异性切断值对于准确诊断外科手术期间心肌损伤至关重要.
- 实施性别特定的门可以改善接受CABG的妇女的结果.
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