系统性审查:益生菌对抗生素诱导的微生物组破坏的影响
J Łukasik1, T Dierikx2, B C Johnston3,4
1Department of Paediatrics, 37803The Medical University of Warsaw, Żwirki i Wigury 63A, 02-091 Warsaw, Poland.
Beneficial microbes
|July 4, 2024
概括
益生菌在抗生素治疗后恢复肠道微生物群的有效性不确定. 结果各不相同,一些研究表明没有益处,甚至对微生物多样性和功能产生负面影响.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素的使用经常会扰乱肠道微生物群,导致失生症.
- 益生菌在减轻或逆转抗生素诱导的微生物组变化的有效性尚未得到充分证实.
- 通过益生菌完全恢复微生物组的说法可能被夸大了.
研究的目的:
- 系统地审查有关益生菌在预防或改善抗生素诱导微生物组破坏方面的有效性证据.
- 评估益生菌在抗生素治疗后对微生物组合,多样性,功能和耐药性的影响.
主要方法:
- 搜索了Medline,Embase和CENTRAL的随机对照和非随机试验.
- 包括接受全身抗生素的任何年龄段的参与者,具有低基线失生症风险.
- 干预涉及在抗生素治疗期间或之后的益生菌,与安慰剂或没有干预相比.
主要成果:
- 审查了七项研究 (八篇论文);结果高度异质.
- 益生菌对微生物群多样性的影响范围从抵消变化到加剧变化或没有影响.
- 对微生物种群数量和功能的影响各不相同,没有观察到一致的积极结果.
- 耐药性评估显示出混合的结果,其中一项研究报告没有影响,另一项研究报告抗生素耐药性基因的增加.
结论:
- 异质的发现排除了关于益生菌在抗生素诱导的微生物群恢复中的有效性的最终结论.
- 需要使用先进的分子方法和更大,更多样化的种群进行标准化,长期的研究.
- 定义一个健康的微生物群和将微生物变化与临床结果联系起来,对于未来的临床应用至关重要.
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