肥胖,无脂肪质量和50万个人的发生性心力衰竭
Ayodipupo S Oguntade1,2, Hannah Taylor3, Ben Lacey3,4
1Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK ayodipupooguntade@gmail.com.
Open heart
|July 4, 2024
概括
中枢脂肪和多余的身体脂肪显著增加心力衰竭 (HF) 的风险. 无脂肪质量与HF的关联主要是由于脂肪质量,脂肪分布对HF亚型的影响不同.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 身体脂肪分布和无脂肪质量在心力衰竭 (HF) 风险中的独特作用需要澄清.
- 了解这些人体组成因素对于预测和预防高频率至关重要.
研究的目的:
- 调查各种身体组成部分对发展HF风险的独立贡献.
- 探索身体脂肪分布如何影响不同的HF亚型.
主要方法:
- 对428,087名英国生物库参与者的分析,随访时间中位数为13.8年.
- 使用调整后的考克斯比例危险回归模型来评估身体组成和事件HF之间的关联.
- 检查的措施包括腰围 (WC),体重指数 (BMI),身体脂肪,无脂肪质量,内脏脂肪 (VAT) 和皮下脂肪.
主要成果:
- 肝炎风险与中央脂肪率 (调整为BMI的WC) 比一般脂肪率 (调整为WC的BMI) 有更强的联系.
- 内脏脂肪 (VAT) 显示与HF风险的独立关联,即使经过对皮下脂肪进行调整.
- 保持射出分数的HF与所有脂肪测量相关,而减少射出分数的HF与脂肪测量没有独立相关.
结论:
- 过多的脂肪和脂肪质量是增加HF风险的关键因素.
- 无脂肪质量与HF风险之间的关联似乎在很大程度上可以通过与脂肪质量的相关性来解释.
- 身体脂肪分布与HF亚型具有独立的相关性,表明不同的潜在致病机制.
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