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[乙型肝炎病毒感染与不良妊娠结果之间的相关性-系统性审查和元分析]

W Q Cai¹, K Y Mao¹, P Y Jiang¹

¹Department of Digestive Diseases, Union Hospital of Fujian Medical University, Fuzhou 350001, China.

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

|July 4, 2024

概括

孕妇感染乙型肝炎病毒 (HBV) 会增加诸如妊娠期糖尿病和早产等不良结果的风险. 新生儿并发症,如窒息,在感染HBV的母亲中也更为常见.

科学领域:

产科和妇科产科和妇科
传染性疾病传染性疾病
周围生理学周围生理学

背景情况:

乙型肝炎病毒 (HBV) 感染是一个全球性的健康问题.
了解HBV对怀孕结果的影响对于母亲和新生儿健康至关重要.

研究的目的:

系统地评估HBV感染与不良妊娠和新生儿结局之间的关联.
量化 HBV 感染孕妇特定并发症的风险.

主要方法:

在主要数据库 (PubMed,Embase,Web of Science,Cochrane) 进行全面的文献搜索.
48项研究的元分析和累积元分析,涉及超过92,000名HBsAg阳性和700万名HBsAg阴性孕妇.
使用固定/随机效应模型的统计分析和出版偏差的评估.

主要成果:

乙型肝炎病毒感染与妊娠糖尿病 (OR=1.34) 和肝脏内胆固醇症 (OR=2.48) 有显著的相关性.
新生儿窒息的风险增加 (OR=1.49) 和早产 (OR=1.22) 观察到HBV感染母亲的新生儿.
累积元分析表明,妊娠期糖尿病和早产分别在2009年和2010年后存在稳定的风险.

结论:

怀孕妇女的HBV感染与肝脏内胆固醇症,妊娠糖尿病,新生儿窒息症和早产的风险更高有关.
这些发现强调了在孕妇人群中管理HBV的重要性.
早期识别和管理策略对于减轻不良结果至关重要.

关键词:

乙型肝炎病毒的感染.进行元分析分析.怀孕怀孕怀孕怀孕

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