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数据可靠性和诊断性能的样本大小计算:一次全面的审查.
Caterina Beatrice Monti1, Federico Ambrogi2,3, Francesco Sardanelli3,4
1Postgraduation School in Radiodiagnostics, University of Milan, Milan, Italy. caterinab.monti@gmail.com.
计算正确的样本大小对于研究精度和统计能力至关重要. 本综述提供了可靠性和诊断性能研究中样本大小计算的可访问方法.
科学领域:
- 生物统计学 生物统计学
- 医学研究方法学 医学研究方法学
背景情况:
- 样本大小的确定对于研究有效性和伦理考虑至关重要.
- 样本规模不足可能导致研究能力不足,浪费资源,并可能损害参与者.
研究的目的:
- 为数据可靠性和诊断性能研究提供样本大小计算方法的综述.
- 为这些领域的研究人员提供实用指导和可访问的方法.
主要方法:
- 审查已建立的统计方法来计算样本大小.
- 考虑可靠性指标 (科恩的 κ,ICC,布兰德-阿尔特曼) 和诊断性能指标 (精度,灵敏度,特异性,ROC曲线).
- 讨论特殊情况,包括退出,多个终点和非标准错误值.
主要成果:
- 介绍了计算可重复性/可复制性和诊断准确性的样本大小的方法.
- 为各种场景提供指导,包括比较和估计.
- 包括用于常见计算的免费软件示例.
结论:
- 适当的样本大小计算对于确保研究结果的质量和可靠性至关重要.
- 本综述是研究人员需要确定特定研究类型的样本大小的实用资源.
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