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Updated: Jun 22, 2025

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

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对于中性粒细胞和巨细胞中RIPK1-依赖性热的差异信号要求

See Jie Yow1,2, Safwah Nasuha Rosli1,2, Paul E Hutchinson2

  • 1Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Cell death & disease
|July 4, 2024
PubMed
概括

骨髓状细胞在Yersinia感染期间使用不同的信号通路进行细胞死亡和细胞因子释放. 中性粒细胞依赖TNFR1,而巨细胞利用TNFR1和TLR4-TRIF信号,揭示细胞特异性免疫反应.

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Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

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Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells09:15

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Immune Surveillance by NK Cells and Phagocytes

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