在动物中,des-acyl ghrelin降低了酒精摄入量和酒精诱导的奖励
Sarah Witley1, Christian E Edvardsson1, Cajsa Aranäs1
1Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Translational psychiatry
|July 4, 2024
概括
脱酸格林 (DAG) 降低了动物的酒精消耗和相关的奖励行为,与格林形成鲜明对比.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 行为药理学行为药理学
背景情况:
- 酒精使用障碍 (AUD) 的机制很复杂,格林因酒精奖励增强而导致.
- 主要循环形式的des-acyl ghrelin (DAG) 在奖励过程中起着未知的作用.
- 以前的研究表明,DAG减少了食物摄入量.
研究的目的:
- 为了研究des-acyl ghrelin (DAG) 对动物模型中与酒精有关的行为的影响.
- 探索DAG在奖励处理和神经传递中的作用.
- 为了确定DAG的潜在分子点.
主要方法:
- 给雄性和雌性大鼠使用des-acyl ghrelin (DAG).
- 评估酒精消费,运动活动,条件偏好和多巴胺水平.
- 在腹膜区域和核 accumbens 中的神经递质分析.
- 电生理学和约束性测试以确定DAG目标.
主要成果:
- 在雄性和雌性大鼠中,DAG剂量依赖性降低了酒精饮用.
- DAG减弱了酒精诱导的运动器刺激,有条件的位置偏好和多巴胺释放.
- DAG没有影响酒精奖励记忆或海马神经传递.
- DAG没有与单胺转运体,5HT2A,CB1或μ-阿片类受体结合.
结论:
- 脱酸格林 (DAG) 减弱了动物与酒精相关的反应,反对格林的作用.
- DAG影响奖励处理,但不影响与酒精有关的记忆巩固.
- 这些发现加深了对 ghrelinergic 系统在调节酒精行为的作用的理解.
更多相关视频
08:45Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
Published on: November 8, 2024
549
05:40The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Published on: April 28, 2022
3.0K
相关概念视频
01:30Regulation of Food Intake
216
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
216
01:27CNS Depressants: Alcohol and Nicotine
201
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
201
01:24Glucagon-like Receptor Agonists
313
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
313