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Updated: Jun 22, 2025

Mass Spectrometric Analysis of Glycosphingolipid Antigens
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通过选择性丰富和在多结构层面上进行分析来照亮中性糖脂体的黑暗空间

Zidan Wang1, Donghui Zhang2, Junhan Wu2

  • 1MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Nature communications
|July 4, 2024
PubMed
概括

这项研究引入了一种新的方法来分析大脑组织中的糖类脂质 (GSL),从而能够详细地绘制和区分质瘤亚型. 通过先进的脂质学分析,可以识别特定疾病的GLS变化.

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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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