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在瑞典的一般老年人群中,脉压升高之前发生的慢性病事件
Tomas Månsson1, Aldana Rosso2, Katarina Ellström2
1Division of Geriatric Medicine, Department of Clinical Sciences in Malmö, Lund University and Skåne University Hospital, Jan Waldenströms Gata 35, pl 13, 205 02, Malmö, Sweden. tomas.mansson@med.lu.se.
Scientific reports
|July 4, 2024
概括
老年人脉压升高 (PP) 与患慢性病 (CKD) 的风险更高有关. 这项研究发现,80 mmHg或更高的PP显著增加了发生CKD的可能性.
科学领域:
- 心血管健康 心血管健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年病的医生 老年病的医生
背景情况:
- 动脉硬 (AS) 和慢性病 (CKD) 在老年人群中很普遍.
- 脉压 (PP) 升高,这是AS的标志物,与高血压有关,可能会影响功能,因为脏的血管阻力较低.
- 脏对脉动压力和高血压的脆弱性需要对PP和脏健康之间的联系进行研究.
研究的目的:
- 检查高脉压 (PP) 与慢性病 (CKD) 发生率之间的关联.
- 在老年人群中研究PP升高与全因死亡率之间的关系.
- 为了确定更高的PP水平是否预测未来的功能下降.
主要方法:
- 使用了来自该项目的数据.
- 在斯卡内 (Skåne) 度过美好的衰老.
- 一般人口队列研究.
- 采用Cox比例危险回归模型,根据年龄,性别,糖尿病和吸烟习惯进行调整.
- 分析了三种PP水平对发生性CKD (n=2693) 和全因死亡率 (n=5253) 的影响.
主要成果:
- 高PP≥80mmHg显著与发生CKD的风险增加有关 (危险比率1.59,95%CI1.28-1.97).
- 在高PP (≥80 mmHg) 和全因死亡率之间没有发现显著的关联.
- 相比之下,PP<60 mmHg显示发生性CKD的中位生存时间为18.7年.
结论:
- 高脉压 (PP) ≥80 mmHg是老年人患慢性病 (CKD) 的重要危险因素.
- 在老年人中监测PP可以帮助识别那些功能下降风险较高的人.
- 进一步的研究可能会探索治疗PP和预防CKD进展的干预措施.
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