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Updated: Jun 22, 2025

TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
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招募FBXO22用于针对性的NSD2降解

David Y Nie1,2,3, John R Tabor4, Jianping Li5,6

  • 1Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.

Nature chemical biology
|July 4, 2024
PubMed
概括

一种新的向蛋白质降解 (TPD) 策略使用UNC8732来招募FBXO22,降解白血病细胞中的致癌性NSD2蛋白质. 这种方法对治疗特定癌症和开发新的TPD疗法具有前途.

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