过早出生或出生体重低的个体的长期健康状况:一个队列研究
Coralie Amadou1, Pierre-Yves Ancel2,3, Jennifer Zeitlin2
1Department of diabetes and endocrinology, Sud-Francilien Hospital, Corbeil-Essonnes (91 100), Paris-Saclay University, Orsay, France. coralie.amadou@u-psud.fr.
Pediatric research
|July 4, 2024
概括
过早分娩增加了成人肥胖和其他健康问题的风险. 非早产期低出生体重与糖尿病和高血压有关,但不与肥胖有关.
科学领域:
- 生殖健康 生殖健康
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 研究早产和非早产低出生体重 (LBW) 的长期健康后果.
- 了解出生环境对成年人健康结果的独特影响.
研究的目的:
- 测量早产和非早产LBW与成人几种长期健康结果的关联.
- 为了区分早产与LBW的长期健康影响与其他原因.
主要方法:
- 利用了来自Consstances队列的数据,其中包括30,295名成年参与者.
- 采用修改后的Poisson回归来评估早产 (<37周) 和LBW (<性别特异性第10百分位) 与各种健康结果之间的关联.
- 根据参与者的年龄和父母病史进行了调整,并测试了基于性别的相互作用影响.
主要成果:
- 过早分娩 (5.2%) 与肥胖,高三糖血症,高LDL胆固醇,高血压 (HBP),代谢综合征,非酒精性脂肪肝疾病,过敏症状和较低教育程度的风险增加有关.
- 非预期的LBW与糖尿病前期/糖尿病,HBP和教育程度较低的风险有关.
- 相反,非预产期的LBW与肥胖和腹部肥胖的风险降低有关;女性患高三糖血和代谢综合征的风险更高.
结论:
- 早产和非早产LBW都被确定为多种不良成年健康结果的风险因素.
- 对脂肪储存的长期影响似乎是早产 (风险增加) 和非早产LBW (风险降低) 的相反方向.
- 研究结果强调了在评估长期健康风险时考虑低出生体重的原因的重要性,特别是在肥胖方面.
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