TFEB控制着胎盘中同胞性热细胞的形成和激素的产生
Marcella Cesana1,2, Gennaro Tufano3, Francesco Panariello3
1Telethon Institute of Genetics and Medicine (TIGEM), 80078 Pozzuoli, Naples, Italy. m.cesana@tigem.it.
Cell death and differentiation
|July 4, 2024
概括
转录因子EB (TFEB) 对于胎盘发育至关重要,促进同胞性细胞的形成和功能. 由于胎盘缺陷,其损失导致胚胎死亡.
科学领域:
- 发展生物学 发展生物学
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 转录因子EB (TFEB) 调节自和溶酶体功能,影响细胞代谢.
- 在小鼠中,TFEB缺乏导致与胎盘异常相关的胚胎死亡,包括血管缺陷和缺氧.
- TFEB在胎盘发育中的作用背后的精确分子机制以前是未知的.
研究的目的:
- 阐明TFEB影响胎盘发育和功能的分子机制.
- 为了研究TFEB在同胞细胞的形成和内分泌活性中的作用.
- 要了解TFEB如何调节胎盘基因表达,这对胚胎发育至关重要.
主要方法:
- 在TFEB淘汰赛小鼠体内分析.
- 多omics方法 (例如,转录组学,蛋白质组学).
- 试管合成化模型和功能测试.
主要成果:
- 构成性TFEB的损失导致缺陷的同聚类细胞层的形成.
- TFEB在同胞性热细胞发育过程中转移到核中,并与关键的胎盘基因促进体 (Syncytin-1,Syncytin-2,CYP19A1) 结合.
- 缺少TFEB会影响热囊细胞的融合,减少胎盘激素的分泌,降低17β-雌二醇 (E2) 的产生.
结论:
- TFEB对于胎盘发育至关重要,调节热囊细胞融合和内分泌功能.
- TFEB控制了合成细胞的认同和激素合成的转录程序.
- TFEB的作用对于通过胎盘功能来满足胚胎发育的生物能量需求至关重要.
更多相关视频
12:02Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
15.9K
08:26Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
Published on: August 31, 2016
7.8K
相关概念视频
Gonadal and Placental Hormones
1.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.4K
TGF - β Signaling Pathway
7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K
Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Ovarian Cycle
1.1K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.1K
