在高血压患者中,阻塞性睡眠呼吸暂停和心律失常以及心率变化之间的关联
Shao-Dong Xu1, Ling-Li Hao2, Fei-Fei Liu2
1Department of Cardiology, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, 230001, China. xnkxsd@163.com.
BMC cardiovascular disorders
|July 4, 2024
概括
患有严重阻塞性睡眠呼吸暂停 (OSA) 的高血压患者面临着心房律乱和左心房扩张的更高风险. 心率变化 (HRV) 与这一群体的OSA严重程度有显著的相关性.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 内部医学 内部医学
背景情况:
- 在高血压患者中,阻塞性睡眠呼吸暂停 (OSA) 与心律不整和心率变化 (HRV) 等心脏问题之间的联系仍然不清楚.
- 这项研究旨在调查高血压患者的OSA,心律失常和HRV之间的关联.
研究的目的:
- 确定OSA严重程度与高血压患者心律不整的发生之间的关系.
- 评估OSA对高血压个体心率变化 (HRV) 参数的影响.
- 探索OSA和心脏结构变化之间的相关性,特别是左心房直径.
主要方法:
- 对高血压患者进行了横截面分析,根据他们的呼吸暂停-呼吸暂停指数 (AHI) 分类为AHI ≤15和AHI>15组.
- 参与者进行了综合评估,包括多睡眠图 (PSG),24小时动态心电图 (DCG) 和心脏多普勒超声波.
- 使用统计分析,包括单变量和多变量线性回归,以确定OSA参数和心脏结果之间的关联.
主要成果:
- 与AHI ≤ 15组相比,AHI > 15的患者表现出 significantly 显著更高的心房早跳和心房低心率的流行率.
- 观察到HRV参数的显著差异,AHI>15组显示正常至正常R-R间隔 (SDNN) 和SDANN的标准偏差较高.
- 低频 (LF) 和高频 (HF) 组件的升高,以及LF/HF比率,在AHI>15组中被发现,与显著更大的左心脏直径 (LAD) 一起.
结论:
- 患有AHI> 15的高血压患者患心房律乱和左心房扩张的风险增加.
- 心率变化 (HRV) 与高血压患者阻塞性睡眠呼吸暂停 (OSA) 的严重程度有显著的相关性.
- 这些发现强调了在高血压患者中进行OSA查的重要性,以减轻心脏风险.
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