在皮层麻醉中比较不同度的罗皮瓦卡因用于皮肤透过膜内切除术:一个随机对照试验
Fengyan Shen1, Yuju Pu1, Zhiming Lan2
1Department of Anesthesiology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, 518033, Guangdong, China.
BMC anesthesiology
|July 4, 2024
概括
与0.3%相比,0.4%的罗皮瓦卡因度提供了优异的疼痛缓解,并且在皮肤外转内切除术 (PTED) 期间需要更少的芬太尼,而0.3%的罗皮瓦卡因度则提供了优异的疼痛缓解. 由于其有效性和安全性,推使用这种度的PTED.
科学领域:
- 麻醉学 麻醉学
- 神经外科 神经外科
- 疼痛管理 疼痛管理
背景情况:
- 穿皮转膜内切除术 (PTED) 是一种微创脊柱手术.
- 在PTED中确定用于外周麻醉的最佳罗皮瓦卡因度对于患者的治疗结果至关重要.
研究的目的:
- 在接受PTED的患者中,比较0.3%和0.4%的罗皮瓦卡因外周麻醉的疗效和安全性.
- 为了确定PTED程序的最佳罗皮瓦卡因度.
主要方法:
- 一项随机对照试验,涉及70名患者,他们接受了第一次PTED.
- 患者接受了0.3%或0.4%的罗皮瓦卡因外周麻醉.
- 主要结局包括数值评分表 (NRS) 疼痛评分和部延伸水平 (HEL);次要结局是手术内芬太尼尔剂量和术后并发症.
主要成果:
- 与0.3%组相比,0.4%的罗皮瓦卡因组显示出明显较低的NRS得分 (P < 0.01) 和较高的HEL得分 (P < 0.001).
- 在0.4%的小组中,手术内芬太尼的剂量明显较低 (P < 0.01).
- 术后并发症在0.4%组 (2名患者) 与0.3%组 (5名患者) 相比较低.
结论:
- 虽然0.4%的罗皮瓦卡因 (20毫升) 可能会暂时影响肌肉力量,但它不会阻碍PTED手术.
- 0.4%的罗皮瓦卡因显示出卓越的止痛性能和PTED的有利安全概况.
- 建议0.4%的罗皮瓦卡因度用于PTED的临床使用.
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