后COVID综合征的流行:系统性审查和元分析
Ruhana Sk Abd Razak1, Aniza Ismail2,3, Aznida Firzah Abdul Aziz4
1Department of Public Health Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak, Cheras, Kuala Lumpur, 56000, Malaysia.
BMC public health
|July 4, 2024
概括
后COVID综合征 (PCS) 在COVID-19感染后影响超过40%的个人. 这一系统性审查和元分析提供了全球流行率估计,突出了长期COVID的重大健康负担.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 由于COVID-19的流行,从感染中恢复过来的个体数量增加了.
- 后COVID综合征 (PCS) 被定义为感染后12周以上持久的迹象和症状,其他诊断无法解释.
- 全球PCS的流行已经成为一个重大的公共卫生问题.
研究的目的:
- 系统地审查和确定全球后COVID综合征 (PCS) 的综合流行率估计.
- 从已发表的文献中合成数据,以了解PCS的全球影响.
- 基于现有研究,提供PCS流行情况的全面概述.
主要方法:
- 在主要数据库 (Web of Science,Scopus,PubMed,Cochrane Library,Ovid MEDLINE) 中进行了系统的搜索.
- 包括在2020年1月至2024年4月期间发表的研究,涉及12周或更长时间评估的COVID-19确诊病例.
- 使用随机效应模型的元分析来估计PCS的综合流行率.
主要成果:
- 48项研究符合资格标准;16项研究被纳入了元分析.
- 全球PCS的综合患病率估计为41.79% (95% CI: 39.70-43.88%).
- 患病率因随访时间,性别和大陆地区而异,女性和特定地区的估计较高.
结论:
- 这些发现为全球PCS的流行率提供了关键的估计.
- 这些估计可以为进一步的研究和PCS管理策略的开发提供信息.
- 解决PCS对于减轻其对人口健康和经济负担的影响至关重要.
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