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运动反应基因的DNA甲基化在训练有素和未训练有素的男性之间有所不同

Carla Geiger^1,2,3, Maria Needhamsen⁴, Eric B Emanuelsson¹

¹Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

|July 4, 2024

概括

骨肌肉的表观遗传学在耐力和抵抗训练之间存在差异. 基线DNA甲基化模式影响运动后的基因表达,影响长期训练适应.

科学领域:

运动科学运动科学
分子生物学分子生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

长期训练适应受分子机制的影响,包括表观遗传学.
了解骨肌肉训练适应中的表观遗传学需要进一步的研究.
这项研究比较了耐力训练,抵抗训练和未训练个体的表观遗传特征.

研究的目的:

研究长期训练有素运动员与未训练有素对照者的骨肌肉DNA甲基化.
检查表观遗传学在耐力和抵抗训练适应中的作用.
评估基线DNA甲基化和对急性运动的基因表达反应之间的关联.

主要方法:

对耐力训练,抵抗训练和年龄相匹配的未受训练个体的骨肌肉DNA甲基化分析.
检查基因甲基化和与肌体发生,基因调节,血管生成和新陈代谢相关的基因表达.
训练和未训练组之间的甲基化模式和基因表达的比较,以及对急性运动的反应.

主要成果:

与抵抗训练运动员和对照人群相比,耐力训练运动员表现出更多的甲基化和基因表达差异.
与缓慢缩纤维相关的特定基因 (MYH7,MYL3) 在耐力运动员中具有较低的甲基化和更高的表达.
调节基因 (FOXO3,CREB5,PGC-1α) 的基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因

结论:

耐力和抵抗训练会诱导不同的骨肌肉DNA甲基化特征.
骨肌肉纤维类型的分布与纤维类型特定基因的甲基化有关.
骨肌的基线DNA甲基化景观在急性运动期间影响基因转录.

关键词:

通过DNA甲基化.酶性甲基测序酶性甲基测序表观基因组学是指表观基因组学.运动运动运动.基因表达基因表达基因表达培训培训培训培训培训

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