热敏水凝中的鼻内双体:促进了对抑郁症管理的desvenlafaxine succinate输送
Tayseer M El-Nawawy1, Yomna A Adel1, Mahmoud Teaima2
1Department of Pharmaceutics, Egyptian Drug Authority (EDA), Cairo, Egypt.
Pharmaceutical development and technology
|July 5, 2024
概括
这项研究开发了携带Desvenlafaxine Succinate (D.V.S.) 的鼻内双体. 在粘膜凝中. 这种新的配方增强了直接鼻到脑的输送,改善了抑郁症的治疗.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 神经科学是一个神经科学.
背景情况:
- 抑郁症是全球残疾的主要原因,传统的抗抑郁药治疗在大脑输送方面面临挑战.
- 德斯文拉法辛糖酸 (D.V.S.) 是一种 是一种抑制神经递质再吸收的抗抑郁药,但与大脑透作斗争.
- 比洛索姆,纳米纤维由胆汁盐稳定,提供多功能药物输送潜力.
研究的目的:
- 为了配制装载着德斯文拉法辛糖酸盐 (D.V.S.D.V.S. Succinate) 的鼻内双体体. ) 的情况.
- 为了将这些双体体纳入粘膜粘合剂的in situ凝,以直接提供鼻至大脑.
- 为了提高抗抑郁药的生物可用性和对治疗抑郁症的脑向.
主要方法:
- 使用薄膜水化方法和l-最佳设计,使用desvenlafaxine载荷的双体细胞组进行了准备.
- 优化双体体的特征是粒子大小,Zeta潜力和封装效率.
- 进行了ex vivo和in vivo的药理动力学研究,以评估大脑吸收.
主要成果:
- 优化双体体的粒子大小为311.21 ± 0.42 nm,Zeta潜力为-37.35 ± 0.43%,封装效率为99.53 ± 0.41%.
- 药理动力学研究表明,大脑对D.V.S.的吸收显著增强. 与免费药物相比. 与免费药物相比. 与免费药物相比.
- 鼻内粘粘在位凝配方促进了直接鼻到脑药物输送.
结论:
- 在粘膜凝中的D.V.S.-loaded双体体的鼻内注射是直接鼻到脑输送的有希望的策略.
- 这种方法改善了Desvenlafaxine Succinate用于潜在的抑郁症治疗的脑部生物可用性.
- 开发的双体配方提供了一种方便和有效的方法,用于抗抑郁药物向大脑.
更多相关视频
10:16Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
7.6K
05:44Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
20.1K
相关概念视频
Drug Delivery: Miscellaneous Routes
336
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
336
Drug Delivery: Enteral Route
415
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
415
Factors Affecting Dissolution: Particle Size and Effective Surface Area
794
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
794
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
358
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
358
Drug Delivery: Parenteral Route
476
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
476
