在人体器官芯片平台中模拟漫长宇宙辐射的影响
Daniel Naveed Tavakol1, Trevor R Nash1, Youngbin Kim1
1Department of Biomedical Engineering, Columbia University, New York, NY, 10032, USA.
概括
银河系宇宙辐射对宇航员构成风险. 使用多器官在芯片技术的"芯片上的宇航员"模型揭示了对长期太空辐射的独特基因反应,有助于制定保护措施.
科学领域:
- 太空医学 太空医学
- 辐射生物学 辐射生物学
- 生物工程是生物工程.
背景情况:
- 银河系宇宙辐射 (GCR) 对长期太空任务上的宇航员构成重大健康风险.
- 了解GCR对人类生理学的影响,需要复制人类器官反应的先进实验模型.
研究的目的:
- 研究长期暴露于太空辐射对人类器官系统的生理影响.
- 开发和利用一个新的多器官芯片 (multi-OoC) 平台作为"太空人芯片"模型.
主要方法:
- 通过人类骨髓,心肌和肝脏组织模型设计了一个多OoC平台.
- 这些组织通过血管循环连接在一起,并暴露在长时间的中子辐射中,模拟深空条件.
- 分析了来自工程骨髓的循环免疫细胞中的基因表达.
主要成果:
- 与急性辐射剂量相比,长时间的中子辐射引起了较大的组织功能偏差.
- 在工程骨髓衍生免疫细胞中发现了58个独特的基因,这些免疫细胞特异于长时间的中子暴露.
- 多OoC平台成功模拟了系统辐射对多个人体器官的影响.
结论:
- "芯片上的宇航员"模型为研究人类对扩展空间辐射的反应提供了有价值的工具.
- 这个平台可以为针对宇宙辐射伤害的辐射保护策略的开发提供信息.
- 识别特定的基因反应可以提高我们对辐射损伤机制的理解.
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