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1-hexanoyl-LSD (1H-LSD) 的分析和行为特征

Simon D Brandt¹, Pierce V Kavanagh², Sarah Gare³

¹School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.

Drug testing and analysis

|July 5, 2024

概括

研究人员鉴定了1-hexanoyl-LSD (1H-LSD),一种新型的lysergic acid diethylamide (LSD) 衍生物. 1H-LSD在小鼠头部抽反应试验中表现出与ALD-52类似的强度,这表明它作为LSD前剂.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
药用化学医学化学

背景情况:

Lysergic acid diethylamide (LSD) 衍生物正在研究其治疗潜力和受体探测.
一些新的LSD衍生物已经成为娱乐性药物,需要它们的检测和表征.
在LSD中,ergoline支架的N1位置是修改的常见位置,导致各种N1-基衍生物,如1-乙-N,N-二甲基聚胺 (1A-LSD,ALD-52).

研究的目的:

为了分析地描述一种新的N1-酸LSD衍生物,1-hexanoyl-LSD (1H-LSD).
用小鼠头部抽反应 (HTR) 试验评估1H-LSD在体内的行为影响.
为了比较1H-LSD与ALD-52.2等现有的LSD类型的功效.

主要方法:

使用标准实验室技术分析1H-LSD的特征.
在体内评估1H-LSD对C57BL/6J小鼠的行为影响,通过头反应 (HTR) 试验.
在HTR试验中确定1H-LSD的中位有效剂量 (ED50).

主要成果:

1H-LSD在分析上得到了成功的表征.
在小鼠中,1H-LSD诱导了头反应 (HTR).
1H-LSD的中位有效剂量 (ED50) 确定为192.4μg/kg (387nmol/kg),这表明大约等效与ALD-52.

结论:

1H-LSD作为一种前药物,在体内可能被水解成LSD,类似于其他N1-化类型.
这项研究提供了关于1H-LSD的药理学特征的宝贵数据.
需要进一步调查,以确定1H-LSD是否进入了研究化学品市场或正在用于娱乐用途.

关键词:

这是一种LSD,一种LSD.头部抽反应的反应新的精神活性物质.迷幻药物迷幻药物是一种精神药物.

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