预防性抗体在COVID-19疫苗接种后抑制尖端特异性T和B细胞反应
Henrik E Mei1, Axel Ronald Schulz1, Heike Hirseland1
1Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Berlin, Germany.
Journal of medical virology
|July 5, 2024
概括
预防性中和抗体可以抑制对像Spikevax这样的mRNA疫苗的免疫反应. 治疗性抗体治疗会抑制B细胞和T细胞的反应,建议在给予抗体之前进行疫苗接种,以获得最佳的免疫增强.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 积极和被动免疫策略对于管理高危COVID-19患者至关重要.
- 预防性中和抗体和mRNA疫苗免疫性之间的相互作用仍然不清楚.
研究的目的:
- 研究治疗中和抗体 (Casirivimab和Imdevimab) 对mRNA疫苗 (Spikevax) 增强剂免疫反应的影响.
- 为了确定幽默免疫是否影响接种疫苗后的反应性细胞免疫.
主要方法:
- 对接受Spikevax增强免疫接种的患者的CD4 T细胞和B细胞反应的分析.
- 抗体治疗患者和对照组之间的免疫反应的比较.
主要成果:
- 在接受卡西里维马布和Imdevimab治疗的患者中,Spikevax增强免疫导致CD4 T和B细胞反应被抑制.
- 对照组显示显著诱导B细胞和T细胞反应,与抗体治疗患者不同.
- 高水平的先前存在的抗体对促进细胞免疫反应的发展产生了负面影响.
结论:
- 预防性中和抗体可以减弱对mRNA疫苗增强剂的免疫反应.
- 建议进行时间测序,最好在预防性抗体注射之前进行活性疫苗接种,以确保强大的免疫反应.
相关概念视频
Vaccinations
44.3K
Overview
44.3K
Immune Response Against Viral Pathogens
770
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
770
Immunological Memory
584
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
584
Cross-reactivity
31.0K
Overview
31.0K
Humoral Immune Responses
72.5K
Overview
72.5K
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K


