通过Bhattacharya和霍夫曼方法确定一些生物化学测试的参考间隔
Clinical laboratory
|July 5, 2024
概括
确定临床实验室参考间隔 (RI) 的间接方法显示了Bhattacharya和霍夫曼方法之间的良好一致性. 这种方法为,,酸盐,25-氧维生素D和副甲状腺激素测试提供了直接RI测定的可行替代方案.
科学领域:
- 临床化学 临床化学
- 实验室医学 实验室医学
- 生物统计学 生物统计学
背景情况:
- 准确的参考间隔 (RI) 对于解释临床实验室试验至关重要.
- 直接确定RI是复杂的,耗时的和昂贵的.
- 间接方法为建立可靠的RI提供了一个更可行的替代方案.
研究的目的:
- 通过间接方法确定的参考间隔 (RI) 与制造商提供的RI进行比较.
- 用Bhattacharya和Hoffmann方法评估间接RI确定的一致性.
- 评估间接方法对 (Ca), (Mg), (P),25-氧维生素D (25(OH) D) 和副甲状腺激素 (PTH) 试验的适用性.
主要方法:
- 分析了2022年1月至11月的1,520,314项临床试验结果 (Ca,Mg,P,25(OH) D,PTH).
- 使用图基方法清理数据并排除极端值.
- 使用Bhattacharya和Hoffmann方法计算RI,以年龄和性别分层.
主要成果:
- 巴塔查亚和霍夫曼的方法产生了高度一致和兼容的RI结果.
- 在这两种方法中,Ca和Mg RI通常与制造商值保持一致.
- 对于P,25(OH) D和PTH RI,特别是在按性别和方法分层时,发现了差异.
结论:
- 间接的RI确定方法 (Bhattacharya,Hoffmann) 显示出显著的一致性.
- 实验室应该建立特定人群的RI,考虑分析方法,年龄和性别.
- 定期更新RI对于准确的临床试验解释至关重要.
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