处方实践在治疗消耗:从随机试验的二次分析随机试验
Susan M Rattigan1, Kyra H Grantz2, Kerstin Hanson3
1Department of Nutrition, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
BMJ nutrition, prevention & health
|July 5, 2024
概括
严重急性营养不良 (SAM) 的门诊治疗涉及高药物使用率. 在入院时的常规抗生素导致了更多的处方,这表明临床指示的抗生素使用支持SAM计划中谨慎的抗生素管理.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 全球健康 全球健康
背景情况:
- 目前的指导方针建议常规和临床指示药物用于重症急性营养不良 (SAM) 门诊治疗.
- 了解药物模式和常规抗生素的影响对于优化SAM护理至关重要.
研究的目的:
- 描述在门诊SAM治疗期间使用药物的情况.
- 探索入院时常规抗生素对后续药物处方的影响.
主要方法:
- 一个安慰剂控制的双盲试验,涉及2399名SAM儿童.
- 药物被分类,并记录时间/诊断.
- 统计分析比较了阿莫西西林和安慰剂组之间的药物使用情况.
主要成果:
- 74.6%的儿童至少服用了一种处方药.
- 抗发烧药/止痛药,抗疟药和抗生素是最常见的.
- 与阿莫西西林组相比,接受安慰剂的儿童服用的总药物和口服抗生素较少.
结论:
- 在门诊SAM治疗中观察到药物处方的高率.
- 常规抗生素在入院时增加了整体药物使用.
- 临床指示的抗生素处方可能会促进SAM管理中明智的抗生素使用.
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